Yes it can! Currently they have built in integrations for OptimizeMember (OptimizePress), Wishlist Member, Digital Access Pass, & MemberMouse.
Additionally, using the ThriveCart Zapier App, you can also integrate with Teachable, Kajabi, ZippyCourses, and many more powerful Membership systems.
I personally love to use ActiveMember360, which is a membership plugin that works off of ActiveCampaign tags - you can just add a tag to the contact when they purchase and it will automatically grant them membership access. Very powerful system.
You can do the same thing with iMember360/infusionsoft as well.
Endless possibilities here.... If you find something that ThriveCart can't integrate with I'll be shocked.